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Benes FM, McSparren J, Bird ED, SanGiovanni JP, Vincent SL

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From a safety perspective and due to ARA being a known pro-inflammatory fatty acid, use of ARA may be contraindicated in populations that have compromised inflammatory health (i.e., inflammatory bowel syndrome, Chrons disease, etc.)

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In addition, inhibiting GPX4 also promote ferroptosis in some malignant tumor cells such as pancreatic ductal adenocarcinoma (Sui et al., 2018), etc

Overall, stem-celland immune-cellderived secretomes offer a multi-modal, low-immunogenic platform to subdue microglial pyroptosis, but rigorous optimization and head-to-head validation are essential before clinical translation